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- Eric Clapton recorded the guitar solo for The Beatles' “While My Guitar Gently Weeps” at Abbey Road Studios in London.
- Eric Clapton recorded the guitar solo for The Beatles' "While My Guitar Gently Weeps", becoming the first major rock solo guitarist from outside the group to guest on a Beatles recording. George Harrison later said that Clapton's presence encouraged the other members of the band to try harder.
- Pete Townshend joined Eric Clapton on stage in Greensboro, North Carolina; Keith Moon also performed.
- Eric Clapton received a gold record for the album "461 Ocean Boulevard", which contained his No. 1 hit "I Shot the Sheriff". The album was later certified platinum in the U.S. for sales of more than one million copies.
- Eric Clapton reached No. 1 on the US album chart for the first time as a solo artist with the album “461 Ocean Boulevard”, which began a four-week run at the top. The album also reached No. 3 in the United Kingdom, while the single “I Shot the Sheriff” reached the Top 10 in nine countries and became Clapton's only single to reach No. 1 on the Billboard Hot 100.
- Eric Clapton topped the U.S. album chart with „461 Ocean Boulevard“. Also in the Top 10 were John Denver, Elton John, Stevie Wonder, Bachman-Turner Overdrive, Bad Company, Loggins & Messina, Robin Trower, Bob Dylan & The Band and Paul McCartney & Wings.
- Eric Clapton performed at Maple Leaf Gardens in Toronto, Ontario.
- Eric Clapton performed at The Spectrum in Philadelphia, Pennsylvania.
- Eric Clapton performed at Market Square Arena in Indianapolis, Indiana.
- Eric Clapton performed at the Scope arena in Norfolk, Virginia.
- During a performance in Birmingham, England, Eric Clapton publicly expressed support for the right-wing National Front and made racist remarks.
- Eric Clapton performed at the Apollo Theatre in Glasgow, Scotland.
- Eric Clapton performed at Scandinavium in Gothenburg, Sweden.
- Eric Clapton released “Unplugged”, recorded for the MTV Unplugged television series in January of the same year. The album included “Tears in Heaven” and an acoustic version of “Layla”, helped revive his career and became his best-selling album. It reached number one in the US and number two in the UK and sold 26 million copies worldwide.
- Eric Clapton entered the Billboard 200 at No. 1 with his twelfth solo studio album, “From the Cradle”. The album also reached No. 1 in the UK, Austria, and Switzerland. The blues recording followed the success of “Unplugged” and won the 1995 Grammy Award for Best Traditional Blues Album; it was also nominated for Album of the Year.
- The Crossroads Centre, funded by Eric Clapton, opened in Antigua. It provided treatment for people with drug and alcohol addictions and pledged not to turn away anyone who needed help.
- Eric Clapton purchased a 50% stake in the London menswear store Cordings to help save the historic business from closure.
- Eric Clapton released the album “Back Home”, his first album of original material since the 2001 album “Reptile”. Guests on the album included his former Blind Faith bandmate Steve Winwood and Billy Preston. Clapton also included “Love Comes to Everyone” by his late friend George Harrison.
- An oil painting by German artist Gerhard Richter, owned by Eric Clapton, sold at auction for £21 million ($34 million), then an auction record for a work by a living artist. Clapton planned to donate the proceeds to the Crossroads Centre in Antigua, the rehabilitation facility he founded.