Madonna během koncertu v Pontiac Silverdome zastavila vystoupení, aby se omluvila 42 000 fanouškům za své předchozí označení rodného města Bay City v Michiganu za „smelly little town“.
Madonna reached No. 1 on the U.S. Billboard Hot 100 with “Who's That Girl”, her sixth U.S. No. 1 single and also a No. 1 hit in the United Kingdom. It was a Spanish-English song with the refrain “¿Quién es esta niña?” and the title track of the soundtrack album to the comedy film of the same name, in which Madonna starred alongside Griffin Dunne.
Madonna's album True Blue reached No. 1 on the US albums chart, while the single "Papa Don't Preach" began a two-week run at No. 1 on the US singles chart.
Madonna appeared in the film "Shanghai Surprise", which flopped at the box office and was harshly rejected by critics. The film was produced by George Harrison's HandMade Films, and Harrison said of Madonna that she had no sense of humor, which was unfortunate for a comedy.
Madonna's "True Blue," the title track of her album of the same name, reached No. 1 on the UK singles chart. It was her third UK chart-topper. The title came from a favourite expression of her then-husband, Sean Penn, and the song was dedicated to him. Madonna also topped the UK chart that year with "Papa Don't Preach."
Madonna released her debut single “Everybody” on Sire Records, launching her music career. The song did not enter the Billboard Hot 100 but reached No. 3 on the Billboard Hot Dance Club Songs chart, performed well on dance charts and helped Madonna gain her first attention from the music press. It later appeared on her 1983 debut album Madonna.